Cell state · L2
CM.contractile_oxphos
1,131 cells in the full atlas (not the displayed sample).
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Marker genes
ACTC1, ALDOA, CKM, COX4I1, COX6B1, DES, EEF1A2, FTH1, GAPDH, HRC, HSPB6, LDHB, MB, MT-ATP6, MT-ATP8, MT-CO1, MT-CO3, MT-CYB, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MYH7, MYL3, NDUFA4, RPL13, RPL4, RPL8, RPLP1, S100A1, SLC25A4, TCAP, TNNC1, TPM1, TPT1
Annotation genes
ACTC1, ALDOA, CKM, COX4I1, COX6B1, EEF1A2, GAPDH, HRC, LDHB, MYH7, MYL3, NDUFA4, S100A1, SLC25A4, TCAP, TNNC1, TPM1
Annotation rationales
mt-OXPHOS (MT-CO/ND/ATP genes) + nuclear ETC (COX4I1/COX6B1/NDUFA4) indicate robust mitochondrial respiration. SLC25A4 (ANT1) and CKM support the phosphocreatine shuttle; MB augments intracellular O₂ supply. Strong sarcomere (MYH7/ACTC1/TPM1/TNNC1/TCAP) and Ca²⁺ handling (S100A1/HRC) define a ventricular-like, high-endurance phenotype; glycolysis/translation (ALDOA/GAPDH/LDHB; RPL*/EEF1A2) backs biosynthetic demand.
Functional implications
Endurance-grade force generators specialized for sustained afterload against systemic pressure. High ETC flux and efficient energy transfer secure fatigue-resistant contraction, supporting stroke work during exercise and stress. By coupling dense mitochondria with finely tuned Ca²⁺ cycling, they maintain stable output under prolonged demand while minimizing energetic slippage.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.