Cell state · L2
CM.baseline
15,191 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
MYBPC3, PLN, TNNI3, TNNT2, TTN
Annotation genes
MYBPC3, PLN, TNNI3, TNNT2, TTN
Annotation rationales
Core sarcomere and Ca²⁺-handling set: TTN provides passive elasticity and length-dependent activation; MYBPC3 modulates cross-bridge kinetics; TNNI3/TNNT2 regulate thin-filament Ca²⁺ sensitivity; PLN tunes SERCA2a-mediated Ca²⁺ reuptake. Uniform high expression without injury/stress markers denotes the default working-myocyte program.
Functional implications
Steady-state contractile units that sustain rhythmic systolic ejection and diastolic relaxation. They set the baseline for stroke volume and lusitropy, maintaining electrical-mechanical synchrony and foundational cardiac output in the absence of acute stress.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.