Cell state · L2
CHOND.pro_inflammatory
1,459 cells in the full atlas (not the displayed sample).
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Marker genes
BCL2A1, C15orf48, CCL20, CXCL8, CYBA, FCMR, HSD11B1, PILRA, SQOR, TNFAIP8
Annotation genes
CCL20, CXCL8, CYBA, HSD11B1, TNFAIP8
Annotation rationales
CXCL8 (IL-8) and CCL20 recruit neutrophils and CCR6⁺ lymphocytes (e.g., Th17), respectively; CYBA (p22phox) supports NADPH oxidase-dependent ROS generation that fuels cartilage catabolism. HSD11B1 modulates local glucocorticoid tone, affecting inflammation and matrix metabolism; TNFAIP8 links to TNF-responsive survival and inflammatory signaling. This profile typifies inflamed, catabolic chondrocytes seen in symptomatic OA.
Functional implications
Chemokine-orchestrating, catabolic drivers that attract myeloid/T-cell infiltrates from synovium and subchondral bone, amplify ROS-mediated MMP/ADAMTS activation, and deplete proteoglycans, accelerating cartilage softening and fissuring in the knee. Net effect: pain sensitization, swelling, and faster radiographic progression through inflammatory-matrix feedback loops.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.