Cell state · L2
ASTRO.synaptic_interaction
2,266 cells in the full atlas (not the displayed sample).
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Marker genes
ADGRV1, BCYRN1, GOLGA8B, GRIA2, LCNL1, NPIPB13, PLEKHH2, SAT1, SON, SYNE1
Annotation genes
ADGRV1, BCYRN1, GRIA2, LCNL1
Annotation rationales
GRIA2 (AMPAR subunit) and ADGRV1 (adhesion) support a perisynaptic, contact-rich astrocyte interfacing tightly with excitatory synapses; neuron-associated RNAs (BCYRN1, LCNL1) without overt neuronal markers fit an astrocyte specialized for synaptic communication rather than a doublet.
Functional implications
Enhances glutamate clearance near excitatory synapses, modulates AMPAR tone and spine stability, and supports plasticity by shaping perisynaptic ECM/ion microdomains and astrocyte-to-neuron signaling.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.