Cell state · L2
ASTRO.stress_mito
775 cells in the full atlas (not the displayed sample).
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Marker genes
MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L
Annotation genes
MT-ATP6, MT-ATP8, MT-CO1, MT-CO2, MT-CO3, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L
Annotation rationales
Predominance of mitochondrial transcripts indicates high mitochondrial load/oxidative-phosphorylation bias or RNA-quality skew; in astrocytes, this often accompanies oxidative stress, impaired nucleo-cytoplasmic balance, or heightened metabolic demand.
Functional implications
Represents a metabolically strained astrocyte state with potential ROS burden and compromised support capacity; may transiently down-prioritize neurotransmitter clearance while engaging mitochondrial maintenance and damage-control programs.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.