Cell state · L2
ASTRO.stress_acute
1,372 cells in the full atlas (not the displayed sample).
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Marker genes
CRYAB, FOS, HSPA1A, HSPA1B, HSPB8, IRF2BP2, LINC01094, PPP1R15A, PRKAG2, UBC
Annotation genes
CRYAB, FOS, HSPA1A, HSPA1B, PPP1R15A, PRKAG2, UBC
Annotation rationales
Heat-shock chaperones (HSPA1A/B, CRYAB) indicate acute proteotoxic-stress buffering; FOS reflects immediate-early activation; PPP1R15A (GADD34) and PRKAG2 (AMPK regulatory) point to translational control and energy-stress sensing. This constellation is a rapidly induced, reversible shock response that protects astrocyte proteostasis and metabolic integrity.
Functional implications
Provides rapid cytoprotection under oxidative/metabolic insults, stabilizes client proteins to preserve glutamate transporters and gap-junction function, and transiently throttles translation/energy use to maintain astrocyte support of neurons during acute stress.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.