Cell state · L2
ASTRO.neuromodulatory
1,219 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AOC2, CCDC141, EQTN, FOXD4L4, LCNL1, LINC00342, LINC00632, NOS1, PILRA, SPATA45
Annotation genes
AOC2, LCNL1, NOS1, PILRA
Annotation rationales
NOS1 suggests NO signaling capability influencing vascular tone and synaptic efficacy; AOC2 implies amine metabolism; PILRA hints at inhibitory/immune-modulatory input; LCNL1 aligns with neuromodulatory/neuronal-communication machinery without clear neuronal doublet markers.
Functional implications
Tunes neuronal excitability and local blood flow via NO-mediated gliovascular coupling, integrates neuromodulatory cues to gate synaptic activity, and dampens excessive immune activation in neurovascular niches.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.