Cell state · L2
ASTRO.hypoxia_angiogenic
595 cells in the full atlas (not the displayed sample).
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Marker genes
ANGPTL4, C15orf62, GZMM, HILPDA, KCNJ14, LINC01828, LINC02169, MIR194-2HG, MT1HL1, VEGFA
Annotation genes
ANGPTL4, HILPDA, VEGFA
Annotation rationales
VEGFA and ANGPTL4 are classic hypoxia-responsive/angiogenic factors; HILPDA signals lipid/FAO reprogramming under low O₂. This signature maps to astrocytes that sense hypoxia and coordinate vascular remodeling while switching to oxygen-sparing metabolism.
Functional implications
Orchestrates local angiogenesis and perivascular remodeling to restore oxygen delivery, modulates endothelial permeability/BBB dynamics, and adjusts lipid metabolism to sustain neuronal support during ischemia or regional hypoxia.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.