Cell state · L2
ASTRO.homeostatic
2,197 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CPE, FAM171B, GJB6, GPM6A, GPR37L1, HTRA1, SLC1A2, SLC1A4, TSPAN7, TTYH1
Annotation genes
FAM171B, GJB6, GPR37L1, SLC1A2, SLC1A4, TTYH1
Annotation rationales
SLC1A2/1A4 encode high-affinity glutamate/aspartate transporters central to synaptic clearance; GJB6 supports syncytial coupling for K⁺ siphoning; GPR37L1 and FAM171B are canonical astrocyte/homeostatic markers; TTYH1 supports ion conductance. Altogether this indicates a baseline, pro-homeostatic astrocyte maintaining neurotransmitter and ionic balance.
Functional implications
Maintains glutamate uptake and K⁺ buffering, preserves extracellular milieu for reliable synaptic transmission, and sustains neurotrophic support and BBB integrity in the steady state.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.