Cell state · L2
ASTRO.A2_reactive
871 cells in the full atlas (not the displayed sample).
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Marker genes
ARHGAP29, BAALC-AS1, CHI3L1, COLEC12, F3, GNA14, HAP1, NRP1, SAMD4A, TPST1
Annotation genes
CHI3L1, COLEC12, F3, NRP1
Annotation rationales
This profile matches the classic A2 (protective/repair) axis. CHI3L1 (YKL-40) is enriched in A2 astrocytes that arise after ischemia or injury and is associated with neuroprotective/tissue-remodeling signaling. NRP1 (a VEGF co-receptor) and COLEC12 (a scavenger receptor in vascular contexts) indicate strong astrocyte–endothelial crosstalk and angiogenic/repair programs, consistent with BBB restoration. F3 (tissue factor) ties to coagulation and vascular stabilization during wound healing. In contrast to A1 (e.g., C3-high, synapse-pruning), this cluster emphasizes survival, growth, and revascularization, aligning with literature-defined A2 functions.
Functional implications
Supports neuronal survival and synaptic stabilization post-injury, promotes angiogenesis and BBB restoration via astrocyte–endothelial signaling, contributes to debris clearance and ECM reconstitution, thereby accelerating functional recovery.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.