Cell state · L2
ASTRO.A1_reactive
2,169 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ABI3BP, ADAMTSL3, AQP1, C3, CD44, KAZN, LINC00609, NFASC, SLC24A4, VCAN
Annotation genes
AQP1, C3, CD44, VCAN
Annotation rationales
CD44, C3, and VCAN together indicate an A1-like, complement-activating and ECM-remodeling program typical of pro-inflammatory astrocytes; AQP1 is often upregulated in reactive states and can reflect altered water/ion handling. The combination points to a state that amplifies innate immune signaling, strengthens perisynaptic complement tagging (C3), and reshapes the perivascular/perisynaptic matrix via VCAN.
Functional implications
Drives complement cascade engagement at synapses (favoring synaptic pruning/loss), secretes pro-inflammatory mediators, and remodels ECM to limit diffusion and cell motility after injury—linked to neurodegeneration and acute injury; may constrain regeneration while prioritizing containment of damage.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.