Cell state · L2
ASPC.signal_integrator
186 cells in the full atlas (not the displayed sample).
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Marker genes
ABL1, AGAP1, ANK2, ATP13A3, CBLB, ESYT2, GOLGA8A, HIPK2, ITPKC, MIR222HG, NFATC1, NFATC2, PAQR3, PLEKHM2, TSC22D2, WNT9A, ZSWIM6
Annotation genes
ITPKC, NFATC1, NFATC2, WNT9A
Annotation rationales
Calcium–NFAT signaling (ITPKC/NFATC1/2) together with WNT9A suggests a stromal “signal integrator” rather than lineage commitment. These pathways intersect immune and mechanical inputs to set progenitor behavior.
Functional implications
Niche signal modulators. Tune WNT and Ca²⁺–NFAT axes to balance adipogenesis vs fibrosis and couple immune activation to stromal fate decisions; likely influence beigeing and vascular remodeling indirectly.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.