Cell state · L2
ASPC.remodeling
2,351 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
APOC1, AQP3, COL3A1, CYP1B1, FN1, LMO4, LXN, PENK, POSTN, RAB13, RARRES1, TIMP1, TPM2, TUBB3
Annotation genes
COL3A1, FN1, POSTN, RARRES1, TIMP1
Annotation rationales
Strong ECM turnover (COL3A1/FN1/POSTN/TIMP1) with RARRES1 marks fibro-matrix ASPCs that remodel and stiffen the niche; AQP3 suggests fluid balance; PENK hints at neuro-stromal crosstalk.
Functional implications
ECM renovation crew. Rebuilds collagen networks during expansion/repair, supports re-vascularization and nerve patterning; when persistent, promotes fibrosis and mechanical insulin resistance.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.