Cell state · L2
ASPC.preadipocyte_lipid_primed
13,394 cells in the full atlas (not the displayed sample).
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Marker genes
MMP28, CD36, SRPX, FABP5, AKR1C1, TSPAN15, HSPB6, FABP4, CXCL14, MEST, MRPS6, RASD1
Annotation genes
CD36, FABP4, FABP5, MEST, CXCL14, AKR1C1, MMP28, SRPX, TSPAN15, HSPB6, RASD1
Annotation rationales
Adipogenic commitment & lipid handling: CD36 with FABP4/5 marks fatty-acid uptake/trafficking typical of preadipocytes; MEST supports adipogenesis/depot remodeling. Paracrine/angiocrine cueing: CXCL14 indicates stromal adipokine output that recruits vessels/immune cells. ECM/niche remodeling: MMP28 (protease), SRPX (matricellular), and TSPAN15 (adhesion/motility) fit progenitors preparing a differentiation niche. Signal/metabolic tuning: AKR1C1 (steroid/prostaglandin metabolism) modulates differentiation cues; RASD1 (cAMP/glucocorticoid-responsive GTPase) reflects hormonal responsiveness; HSPB6 suggests stress/contractile adaptation in stromal cells. Absence of terminal adipocyte markers (e.g., ADIPOQ, PLIN1/CIDEC, LPL) argues for an early preadipocyte rather than mature adipocyte state.
Functional implications
Niche-priming progenitors that coordinate ECM remodeling and paracrine signaling to enable adipogenesis, while being poised for lipid uptake and storage upon cues. They likely prepare and populate adipogenic foci, attract/support microvasculature and immune partners (via CXCL14), and respond to hormonal/metabolic signals (AKR1C1, RASD1) to progress toward differentiation under energy surplus or remodeling conditions.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.