Cell state · L2
ADIPO.thermogenic
228 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ABCA8, CIDEA, DIO3OS, IFI44L, LAMC1, OAS1, PDK4, RHOBTB3, RSPO3, WDR86
Annotation genes
ABCA8, CIDEA, IFI44L, OAS1, PDK4, RSPO3
Annotation rationales
CIDEA is a hallmark of beige/brown adipocytes that enhances lipid-droplet–mitochondria coupling. PDK4 shunts pyruvate away from PDH toward fatty-acid oxidation, consistent with thermogenesis. ABCA8 suggests increased cholesterol/lipid trafficking during beiging. RSPO3 activates WNT/angiogenic niches supporting beige adipocyte maintenance. Co-expression of OAS1/IFI44L indicates an interferon-stimulated (ISG) tone, a known modifier of thermogenic programs and antiviral readiness in adipose. LAMC1/RHOBTB3 support ECM and organelle trafficking needed for high secretory/oxidative throughput.
Functional implications
Enhance energy expenditure and metabolic flexibility. Oxidize fatty acids and dissipate energy as heat (PDK4-supported FAO; CIDEA-linked thermogenic machinery), improve glucose and lipid handling in the depot, and remodel the vascular/mesenchymal niche (RSPO3, LAMC1) to sustain beiging. The ISG signature suggests cell-intrinsic antiviral readiness without extinguishing thermogenic competence.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.