Cell state · L2
ADIPO.inflammatory
145 cells in the full atlas (not the displayed sample).
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Marker genes
ANGPTL4, EMP1, IFITM3, LMNA, MAFF, MYC, NAMPT, S100A10, SOCS3, STK17A
Annotation genes
ANGPTL4, EMP1, IFITM3, MAFF, MYC, NAMPT, S100A10, SOCS3
Annotation rationales
Adipocytes exposed to cytokines, lipolytic hormones, or fasting mount a stress/inflammatory program. ANGPTL4 promotes lipolysis and modulates vascular/immune interactions; SOCS3 dampens JAK–STAT signaling (often elevated by IL-6), contributing to insulin resistance. IFITM3, MAFF, and MYC indicate interferon/redox/activation responses; NAMPT (visfatin/NAD salvage) supports metabolic stress adaptation and can signal to immune cells. EMP1 and S100A10 mark activation and membrane dynamics seen in cytokine-responsive adipocytes. Classic lipid-storage markers are relatively low, consistent with an activated, catabolic state.
Functional implications
Coordinate immuno-metabolic defense in the depot: increase lipolysis and free-fatty-acid release (ANGPTL4), secrete inflammatory mediators/alarmins, and impose negative feedback on cytokine signaling (SOCS3). Shape macrophage/T cell recruitment and promote depot-wide insulin resistance during stress or obesity, while sustaining NAD metabolism (NAMPT) for survival.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.